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Target
M-phase inducer phosphatase 1
Ligand
BDBM50181033
Substrate
n/a
Meas. Tech.
ChEMBL_345889 (CHEMBL860850)
IC50
4900±n/a nM
Citation
 Huang, W; Li, J; Zhang, W; Zhou, Y; Xie, C; Luo, Y; Li, Y; Wang, J; Li, J; Lu, W Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett 16:1905-8 (2006) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 1
Synonyms:
CDC25A | Dual specificity phosphatase (Cdc25A) | Dual specificity phosphatase Cdc25A | M-phase inducer phosphatase 1 | MPIP1_HUMAN | phosphatase Cdc25
Type:
Protein
Mol. Mass.:
59090.18
Organism:
Homo sapiens (Human)
Description:
P30304
Residue:
524
Sequence:
MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYEQPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALKRSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASLWTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPKESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL
  
Inhibitor
Name:
BDBM50181033
Synonyms:
3-isopropyl-4-(4-methoxyphenylamino)naphthalene-1,2-dione | CHEMBL207734
Type:
Small organic molecule
Emp. Form.:
C20H19NO3
Mol. Mass.:
321.3698
SMILES:
COc1ccc(NC2=C(C(C)C)C(=O)C(=O)c3ccccc23)cc1 |c:7|
Structure:
Search PDB for entries with ligand similarity: