Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50142488
Substrate
n/a
Meas. Tech.
ChEMBL_345142 (CHEMBL869627)
IC50
21±n/a nM
Citation
Cameron, KO; Lefker, BA; Chu-Moyer, MY; Crawford, DT; Jardine, PD; DeNinno, SL; Gilbert, S; Grasser, WA; Ke, H; Lu, B; Owen, TA; Paralkar, VM; Qi, H; Scott, DO; Thompson, DD; Tjoa, CM; Zawistoski, MP Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats. Bioorg Med Chem Lett 16:1799-802 (2006) [PubMed] Article
More Info.:
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_RAT | Prostanoid EP4 receptor | Ptger4
Type:
PROTEIN
Mol. Mass.:
53381.95
Organism:
Rattus norvegicus
Description:
ChEMBL_1290039
Residue:
488
Sequence:
MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
Inhibitor
Name:
BDBM50142488
Synonyms:
7-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)phenyl)butyl)-5-oxopyrrolidin-1-yl)heptanoic acid | 7-{(S)-2-[(R)-3-Hydroxy-4-(3-trifluoromethyl-phenyl)-butyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid | CHEMBL46395
Type:
Small organic molecule
Emp. Form.:
C22H30F3NO4
Mol. Mass.:
429.4731
SMILES:
O[C@H](CC[C@H]1CCC(=O)N1CCCCCCC(O)=O)Cc1cccc(c1)C(F)(F)F