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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50181295
Substrate
n/a
Meas. Tech.
ChEMBL_345142 (CHEMBL869627)
IC50
65±n/a nM
Citation
 Cameron, KO; Lefker, BA; Chu-Moyer, MY; Crawford, DT; Jardine, PD; DeNinno, SL; Gilbert, S; Grasser, WA; Ke, H; Lu, B; Owen, TA; Paralkar, VM; Qi, H; Scott, DO; Thompson, DD; Tjoa, CM; Zawistoski, MP Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats. Bioorg Med Chem Lett 16:1799-802 (2006) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_RAT | Prostanoid EP4 receptor | Ptger4
Type:
PROTEIN
Mol. Mass.:
53381.95
Organism:
Rattus norvegicus
Description:
ChEMBL_1290039
Residue:
488
Sequence:
MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
  
Inhibitor
Name:
BDBM50181295
Synonyms:
5-(3-((S)-2-(3-hydroxy-4-(naphthalen-2-yl)butyl)-5-oxopyrrolidin-1-yl)propyl)thiophene-2-carboxylic acid | CHEMBL208410
Type:
Small organic molecule
Emp. Form.:
C26H29NO4S
Mol. Mass.:
451.578
SMILES:
OC(CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1ccc2ccccc2c1
Structure:
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