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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50181287
Substrate
n/a
Meas. Tech.
ChEMBL_345142 (CHEMBL869627)
IC50
1202±n/a nM
Citation
 Cameron, KO; Lefker, BA; Chu-Moyer, MY; Crawford, DT; Jardine, PD; DeNinno, SL; Gilbert, S; Grasser, WA; Ke, H; Lu, B; Owen, TA; Paralkar, VM; Qi, H; Scott, DO; Thompson, DD; Tjoa, CM; Zawistoski, MP Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats. Bioorg Med Chem Lett 16:1799-802 (2006) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_RAT | Prostanoid EP4 receptor | Ptger4
Type:
PROTEIN
Mol. Mass.:
53381.95
Organism:
Rattus norvegicus
Description:
ChEMBL_1290039
Residue:
488
Sequence:
MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
  
Inhibitor
Name:
BDBM50181287
Synonyms:
7-((S)-2-((R)-3-hydroxy-4-(3-hydroxyphenyl)butyl)-5-oxopyrrolidin-1-yl)heptanoic acid | CHEMBL203076
Type:
Small organic molecule
Emp. Form.:
C21H31NO5
Mol. Mass.:
377.4745
SMILES:
O[C@H](CC[C@H]1CCC(=O)N1CCCCCCC(O)=O)Cc1cccc(O)c1
Structure:
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