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Target
Segment polarity protein dishevelled homolog DVL-1
Ligand
BDBM50177679
Substrate
n/a
Meas. Tech.
ChEMBL_2237103 (CHEMBL5150999)
Kd
954000±n/a nM
Citation
 Bayle, ED; Svensson, F; Atkinson, BN; Steadman, D; Willis, NJ; Woodward, HL; Whiting, P; Vincent, JP; Fish, PV Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling. J Med Chem 64:4289-4311 (2021) [PubMed] 
Target
Name:
Segment polarity protein dishevelled homolog DVL-1
Synonyms:
DSH homolog 1 | DVL1 | DVL1_HUMAN | Dishevelled-1
Type:
PROTEIN
Mol. Mass.:
75195.46
Organism:
Homo sapiens (Human)
Description:
ChEMBL_468588
Residue:
695
Sequence:
MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSRDGMDNETGTESMVSHRRERARRRNREEAARTNGHPRGDRRRDVGLPPDSASTALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSSAVTRTSSSSLTSSVPGAPQLEEAPLTVKSDMSAVVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSLLKHGFLRHTVNKITFSEQCYYVFGDLCSNLATLNLNSGSSGTSDQDTLAPLPHPAAPWPLGQGYPYQYPGPPPCFPPAYQDPGFSYGSGSTGSQQSEGSKSSGSTRSSRRAPGREKERRAAGAGGSGSESDHTAPSGVGSSWRERPAGQLSRGSSPRSQASATAPGLPPPHPTTKAYTVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMGNPCEFFVDIM
  
Inhibitor
Name:
BDBM50177679
Synonyms:
CHEMBL3814761
Type:
Small organic molecule
Emp. Form.:
C22H18N2O4
Mol. Mass.:
374.3893
SMILES:
OC(=O)c1ccccc1NC(=O)c1cccc(NC(=O)Cc2ccccc2)c1
Structure:
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