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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50181355
Substrate
n/a
Meas. Tech.
ChEMBL_345422 (CHEMBL861116)
IC50
1800±n/a nM
Citation
 Lai, C; Gum, RJ; Daly, M; Fry, EH; Hutchins, C; Abad-Zapatero, C; von Geldern, TW Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase. Bioorg Med Chem Lett 16:1807-10 (2006) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM50181355
Synonyms:
2,5-dichloro-N-(7-(4-hydroxyphenyl)-5-methoxybenzo[d]oxazol-2-yl)benzenesulfonamide | CHEMBL380170
Type:
Small organic molecule
Emp. Form.:
C20H14Cl2N2O5S
Mol. Mass.:
465.307
SMILES:
COc1cc(-c2ccc(O)cc2)c2oc(NS(=O)(=O)c3cc(Cl)ccc3Cl)nc2c1
Structure:
Search PDB for entries with ligand similarity: