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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50181353
Substrate
n/a
Meas. Tech.
ChEMBL_345422 (CHEMBL861116)
IC50
>50000±n/a nM
Citation
 Lai, C; Gum, RJ; Daly, M; Fry, EH; Hutchins, C; Abad-Zapatero, C; von Geldern, TW Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase. Bioorg Med Chem Lett 16:1807-10 (2006) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM50181353
Synonyms:
2,5-dichloro-N-(4-(1,2-dihydropyridin-4-yl)benzo[d]oxazol-2-yl)benzenesulfonamide | CHEMBL204931
Type:
Small organic molecule
Emp. Form.:
C18H13Cl2N3O3S
Mol. Mass.:
422.285
SMILES:
Clc1ccc(Cl)c(c1)S(=O)(=O)Nc1nc2c(cccc2o1)C1=CC=NCC1 |c:26,t:24|
Structure:
Search PDB for entries with ligand similarity: