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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50181356
Substrate
n/a
Meas. Tech.
ChEMBL_345422 (CHEMBL861116)
IC50
32000±n/a nM
Citation
 Lai, C; Gum, RJ; Daly, M; Fry, EH; Hutchins, C; Abad-Zapatero, C; von Geldern, TW Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase. Bioorg Med Chem Lett 16:1807-10 (2006) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM50181356
Synonyms:
CHEMBL381757 | N-(5-tert-butylbenzo[d]oxazol-2-yl)-2,5-dichlorobenzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C17H16Cl2N2O3S
Mol. Mass.:
399.292
SMILES:
CC(C)(C)c1ccc2oc(NS(=O)(=O)c3cc(Cl)ccc3Cl)nc2c1
Structure:
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