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Target
Alkaline phosphatase, placental type
Ligand
BDBM50601822
Substrate
n/a
Meas. Tech.
ChEMBL_2238240 (CHEMBL5152136)
IC50
32±n/a nM
Citation
 Bassi, G; Favalli, N; Pellegrino, C; Onda, Y; Scheuermann, J; Cazzamalli, S; Manz, MG; Neri, D Specific Inhibitor of Placental Alkaline Phosphatase Isolated from a DNA-Encoded Chemical Library Targets Tumor of the Female Reproductive Tract. J Med Chem 64:15799-15809 (2021) [PubMed] 
Target
Name:
Alkaline phosphatase, placental type
Synonyms:
ALPP | Alkaline phosphatase placental type | PLAP | PPB1_HUMAN
Type:
PROTEIN
Mol. Mass.:
57950.65
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1506090
Residue:
535
Sequence:
MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP
  
Inhibitor
Name:
BDBM50601822
Synonyms:
CHEMBL5173145
Type:
Small organic molecule
Emp. Form.:
C25H21Cl2N3O5
Mol. Mass.:
514.357
SMILES:
COc1c(Cl)cc(cc1Cl)-c1cccc(C[C@@H](NC(=O)c2cc([nH]n2)-c2ccc(C)o2)C(O)=O)c1 |r|
Structure:
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