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Target
Ceramide glucosyltransferase
Ligand
BDBM50602025
Substrate
n/a
Meas. Tech.
ChEMBL_2238985 (CHEMBL5152881)
IC50
1.8±n/a nM
Citation
 Wang, J; Reynolds, M; Ibáñez, I; Sasaki, Y; Tanaka, Y; Kikuchi, F; Ohashi, T; Sato, S; Miyabayashi, M; Fujii, T; Tanaka, Y Photoredox-based late-stage functionalization in SAR study for in vivo potent glucosylceramide synthase inhibitor. Bioorg Med Chem Lett 77:0 (2022) [PubMed] 
Target
Name:
Ceramide glucosyltransferase
Synonyms:
CEGT_MOUSE | Ugcg
Type:
PROTEIN
Mol. Mass.:
44844.15
Organism:
Mus musculus
Description:
ChEMBL_809643
Residue:
394
Sequence:
MALLDLAQEGMALFGFVLFVVLWLMHFMSIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPAYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRSYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFSMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
  
Inhibitor
Name:
BDBM50602025
Synonyms:
CHEMBL5181454
Type:
Small organic molecule
Emp. Form.:
C28H27F3N2O4
Mol. Mass.:
512.5202
SMILES:
CC(C)(O)c1ccc(cc1)N1Cc2c(cc(nc2-c2ccccc2OCC(F)(F)F)C2(C)COC2)C1=O
Structure:
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