Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50602810
Substrate
n/a
Meas. Tech.
ChEMBL_2242111 (CHEMBL5156321)
EC50
400±n/a nM
Citation
 Zhou, Z; Ren, Q; Jiao, S; Cai, Z; Geng, X; Deng, L; Wang, B; Hu, L; Zhang, L; Yang, Y; Li, Z Discovery of new and highly effective quadruple FFA1 and PPAR?/?/? agonists as potential anti-fatty liver agents. Eur J Med Chem 229:0 (2022) [PubMed] 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50602810
Synonyms:
CHEMBL5196445
Type:
Small organic molecule
Emp. Form.:
C22H19FO5
Mol. Mass.:
382.3817
SMILES:
COc1ccc(cc1)-c1cccc(OCc2ccc(OCC(O)=O)c(F)c2)c1
Structure:
Search PDB for entries with ligand similarity: