Target
Polyphenol oxidase 2
Ligand
BDBM50183696
Substrate
n/a
Meas. Tech.
ChEMBL_354949 (CHEMBL870122)
IC50
780000±n/a nM
Citation
 Cho, SJRoh, JSSun, WSKim, SHPark, KD N-Benzylbenzamides: a new class of potent tyrosinase inhibitors. Bioorg Med Chem Lett 16:2682-4 (2006) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50183696
Synonyms:
CHEMBL208385 | N-benzyl-3,4,5-trihydroxybenzamide
Type:
Small organic molecule
Emp. Form.:
C14H13NO4
Mol. Mass.:
259.2573
SMILES:
Oc1cc(cc(O)c1O)C(=O)NCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: