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Target
Polyphenol oxidase 2
Ligand
BDBM50183710
Substrate
n/a
Meas. Tech.
ChEMBL_354949 (CHEMBL870122)
IC50
1990000±n/a nM
Citation
 Cho, SJ; Roh, JS; Sun, WS; Kim, SH; Park, KD N-Benzylbenzamides: a new class of potent tyrosinase inhibitors. Bioorg Med Chem Lett 16:2682-4 (2006) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50183710
Synonyms:
CHEMBL207313 | N-benzylbenzamide
Type:
Small organic molecule
Emp. Form.:
C14H13NO
Mol. Mass.:
211.2591
SMILES:
O=C(NCc1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: