Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase Fyn
Ligand
BDBM50602863
Substrate
n/a
Meas. Tech.
ChEMBL_2242297 (CHEMBL5156507)
IC50
2.2±n/a nM
Citation
 Demuro, S; Sauvey, C; Tripathi, SK; Di Martino, RMC; Shi, D; Ortega, JA; Russo, D; Balboni, B; Giabbai, B; Storici, P; Girotto, S; Abagyan, R; Cavalli, A ARN25068, a versatile starting point towards triple GSK-3?/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders. Eur J Med Chem 229:0 (2022) [PubMed] 
Target
Name:
Tyrosine-protein kinase Fyn
Synonyms:
FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn
Type:
Enzyme
Mol. Mass.:
60762.21
Organism:
Homo sapiens (Human)
Description:
P06241
Residue:
537
Sequence:
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
  
Inhibitor
Name:
BDBM50602863
Synonyms:
CHEMBL1997924
Type:
Small organic molecule
Emp. Form.:
C19H18N6S
Mol. Mass.:
362.451
SMILES:
C(Nc1nc(Nc2cc([nH]n2)C2CC2)c2sccc2n1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: