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Target
Chemerin-like receptor 1
Ligand
BDBM50603313
Substrate
n/a
Meas. Tech.
ChEMBL_2243619 (CHEMBL5157829)
IC50
4.8±n/a nM
Citation
 Imaizumi, T; Otsubo, S; Maemoto, M; Kobayashi, A; Komai, M; Takada, H; Sakaida, Y; Otsubo, N Discovery and mechanistic study of thiazole-4-acylsulfonamide derivatives as potent and orally active ChemR23 inhibitors with a long-acting effect in cynomolgus monkeys. Bioorg Med Chem 56:0 (2022) [PubMed] 
Target
Name:
Chemerin-like receptor 1
Synonyms:
CHEMR23 | CHEMR23 | CMKLR1 | CML1_HUMAN | Chemokine-like receptor 1 | DEZ | G-protein coupled receptor ChemR23 | G-protein coupled receptor DEZ
Type:
PROTEIN
Mol. Mass.:
42333.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_100822
Residue:
373
Sequence:
MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML
  
Inhibitor
Name:
BDBM50603313
Synonyms:
CHEMBL5177967
Type:
Small organic molecule
Emp. Form.:
C31H35ClN4O4S2
Mol. Mass.:
627.217
SMILES:
CCNC(=O)c1ccc(Cl)cc1-c1ccc(cc1)[C@@H](C)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1 |r|
Structure:
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