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Target
Chemerin-like receptor 1
Ligand
BDBM50603317
Substrate
n/a
Meas. Tech.
ChEMBL_2243619 (CHEMBL5157829)
IC50
9.1±n/a nM
Citation
 Imaizumi, T; Otsubo, S; Maemoto, M; Kobayashi, A; Komai, M; Takada, H; Sakaida, Y; Otsubo, N Discovery and mechanistic study of thiazole-4-acylsulfonamide derivatives as potent and orally active ChemR23 inhibitors with a long-acting effect in cynomolgus monkeys. Bioorg Med Chem 56:0 (2022) [PubMed] 
Target
Name:
Chemerin-like receptor 1
Synonyms:
CHEMR23 | CHEMR23 | CMKLR1 | CML1_HUMAN | Chemokine-like receptor 1 | DEZ | G-protein coupled receptor ChemR23 | G-protein coupled receptor DEZ
Type:
PROTEIN
Mol. Mass.:
42333.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_100822
Residue:
373
Sequence:
MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML
  
Inhibitor
Name:
BDBM50603317
Synonyms:
CHEMBL5204898
Type:
Small organic molecule
Emp. Form.:
C64H78ClN9O12S2
Mol. Mass.:
1264.94
SMILES:
CCNC(=O)CCC(=O)N1Cc2ccccc2-c2nnn(CCOCCOCCOCCOCCOCCOCCNC(=O)c3ccc(Cl)cc3-c3ccc(cc3)[C@@H](C)N(CC3CC3)c3nc(C(=O)NS(=O)(=O)C4CC4)c(s3)C3CC3)c2-c2ccccc12 |r|
Structure:
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