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Target
G-protein coupled receptor 84
Ligand
BDBM50603901
Substrate
n/a
Meas. Tech.
ChEMBL_2245452 (CHEMBL5159662)
IC50
9.4±n/a nM
Citation
 Chen, LH; Zhang, Q; Xiao, YF; Fang, YC; Xie, X; Nan, FJ Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis. J Med Chem 65:3991-4006 (2022) [PubMed] 
Target
Name:
G-protein coupled receptor 84
Synonyms:
EX33 | G-protein coupled receptor 84 | GPR84 | GPR84_HUMAN | Inflammation-related G-protein coupled receptor EX33
Type:
PROTEIN
Mol. Mass.:
43726.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116040
Residue:
396
Sequence:
MWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHRLH
  
Inhibitor
Name:
BDBM50603901
Synonyms:
CHEMBL5176994
Type:
Small organic molecule
Emp. Form.:
C30H20F2NaO6PS2
Mol. Mass.:
632.567
SMILES:
[Na;v0+].[#6]-[#8]-c1cccc-2c1-[#16]-c1cc(F)ccc1-[#6]=[#6]-2-[#8]P([#8-])(=O)[#8]-[#6]-1=[#6]-c2ccc(F)cc2-[#16]-c2c(-[#8]-[#6])cccc-12 |c:18,t:26|
Structure:
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