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Target
Glutamate receptor ionotropic, kainate 5
Ligand
BDBM50185320
Substrate
n/a
Meas. Tech.
ChEMBL_341792 (CHEMBL861532)
Kd
1880±n/a nM
Citation
 Dolman, NP; More, JC; Alt, A; Knauss, JL; Troop, HM; Bleakman, D; Collingridge, GL; Jane, DE Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists. J Med Chem 49:2579-92 (2006) [PubMed]  Article 
Target
Name:
Glutamate receptor ionotropic, kainate 5
Synonyms:
GRIK5_RAT | Glutamate receptor ionotropic kainate 5 | Grik5
Type:
PROTEIN
Mol. Mass.:
109291.75
Organism:
Rattus norvegicus
Description:
ChEMBL_487966
Residue:
979
Sequence:
MPAELLLLLIVAFANPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLVLRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYPGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGAHGGPQRLLDDPGPPGGPRPQAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGTPAEATSPPRPRPGPTGPRELTEHE
  
Inhibitor
Name:
BDBM50185320
Synonyms:
(S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxyfuran-3-ylmethyl)pyrimidine-2,4-dione | (S)-3-((3-(2-amino-2-carboxyethyl)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)methyl)furan-2-carboxylic acid | CHEMBL206407
Type:
Small organic molecule
Emp. Form.:
C13H13N3O7
Mol. Mass.:
323.2582
SMILES:
N[C@@H](Cn1ccc(=O)n(Cc2ccoc2C(O)=O)c1=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: