Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50185785
Substrate
n/a
Meas. Tech.
ChEMBL_361713 (CHEMBL861444)
Ki
24±n/a nM
Citation
 Ladduwahetty, T; Boase, AL; Mitchinson, A; Quin, C; Patel, S; Chapman, K; MacLeod, AM A new class of selective, non-basic 5-HT2A receptor antagonists. Bioorg Med Chem Lett 16:3201-4 (2006) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM50185785
Synonyms:
4-(2,4-difluorophenethyl)-4-fluoro-1-(4-fluorophenylsulfonyl)piperidine | CHEMBL207064
Type:
Small organic molecule
Emp. Form.:
C19H19F4NO2S
Mol. Mass.:
401.418
SMILES:
Fc1ccc(cc1)S(=O)(=O)N1CCC(F)(CCc2ccc(F)cc2F)CC1
Structure:
Search PDB for entries with ligand similarity: