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Target
Cytochrome c oxidase subunit 1
Ligand
BDBM50140321
Substrate
n/a
Meas. Tech.
ChEMBL_2248532 (CHEMBL5162742)
IC50
280±n/a nM
Citation
 Ye, H; Lv, T; Min, T; Mao, D; Chen, X; Ding, B; Zhang, C HR1405-01, a Safe intravenous NSAID with superior anti-inflammatory and analgesic activities in preclinical trials. Eur J Med Chem 235:0 (2022) [PubMed] 
Target
Name:
Cytochrome c oxidase subunit 1
Synonyms:
COI | COX1_HUMAN | COXI | MT-CO1 | MTCO1
Type:
PROTEIN
Mol. Mass.:
57042.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_746069
Residue:
513
Sequence:
MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS
  
Inhibitor
Name:
BDBM50140321
Synonyms:
(S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phenyl]-propionic acid | CHEMBL441414
Type:
Small organic molecule
Emp. Form.:
C15H20O3
Mol. Mass.:
248.3175
SMILES:
C[C@H](C(O)=O)c1ccc(C[C@H]2CCC[C@@H]2O)cc1
Structure:
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