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Target
Long-chain fatty acid transport protein 4
Ligand
BDBM50186037
Substrate
n/a
Meas. Tech.
ChEMBL_372182 (CHEMBL870441)
IC50
8000±n/a nM
Citation
 Blackburn, C; Guan, B; Brown, J; Cullis, C; Condon, SM; Jenkins, TJ; Peluso, S; Ye, Y; Gimeno, RE; Punreddy, S; Sun, Y; Wu, H; Hubbard, B; Kaushik, V; Tummino, P; Sanchetti, P; Yu Sun, D; Daniels, T; Tozzo, E; Balani, SK; Raman, P Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4. Bioorg Med Chem Lett 16:3504-9 (2006) [PubMed]  Article 
Target
Name:
Long-chain fatty acid transport protein 4
Synonyms:
ACSVL4 | FATP4 | Fatty acid transport protein 4 | S27A4_HUMAN | SLC27A4
Type:
PROTEIN
Mol. Mass.:
72079.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_372182
Residue:
643
Sequence:
MLLGASLVGVLLFSKLVLKLPWTQVGFSLLFLYLGSGGWRFIRVFIKTIRRDIFGGLVLLKVKAKVRQCLQERRTVPILFASTVRRHPDKTALIFEGTDTHWTFRQLDEYSSSVANFLQARGLASGDVAAIFMENRNEFVGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALVFGSEMASAICEVHASLDPSLSLFCSGSWEPGAVPPSTEHLDPLLKDAPKHLPSCPDKGFTDKLFYIYTSGTTGLPKAAIVVHSRYYRMAALVYYGFRMRPNDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRKKFSASRFWDDCIKYNCTIVQYIGELCRYLLNQPPREAENQHQVRMALGNGLRQSIWTNFSSRFHIPQVAEFYGATECNCSLGNFDSQVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGEPGQLVGRIIQKDPLRRFDGYLNQGANNKKIAKDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVEVPGTEGRAGMAAVASPTGNCDLERFAQVLEKELPLYARPIFLRLLPELHKTGTYKFQKTELRKEGFDPAIVKDPLFYLDAQKGRYVPLDQEAYSRIQAGEEKL
  
Inhibitor
Name:
BDBM50186037
Synonyms:
CHEMBL210290 | cyclopentyl 6-methyl-4-(4-(methylthio)phenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C18H22N2O3S
Mol. Mass.:
346.444
SMILES:
CSc1ccc(cc1)C1NC(=O)N=C(C)C1C(=O)OC1CCCC1 |t:13|
Structure:
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