Reaction Details Report a problem with these data
Target
Motilin receptor
Ligand
BDBM50186107
Substrate
n/a
Meas. Tech.
ChEMBL_369515 (CHEMBL865375)
IC50
772±n/a nM
Citation
 Johnson, SG; Gunnet, JW; Moore, JB; Miller, W; Wines, P; Rivero, RA; Combs, D; Demarest, KT Synthesis and SAR of 1,3-disubstituted cyclohexylmethyl urea and amide derivatives as non-peptidic motilin receptor antagonists. Bioorg Med Chem Lett 16:3362-6 (2006) [PubMed]  Article 
Target
Name:
Motilin receptor
Synonyms:
G-protein coupled receptor 38 | GPR38 | MLNR | MTLR | MTLR1 | MTLR_HUMAN
Type:
PROTEIN
Mol. Mass.:
45365.95
Organism:
Homo sapiens (Human)
Description:
ChEMBL_122664
Residue:
412
Sequence:
MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
  
Inhibitor
Name:
BDBM50186107
Synonyms:
CHEMBL169509 | rac-1-((3-(N-benzylpivalamido)cyclohexyl)methyl)-3-(4-fluorophenyl)-1-(3-(2-morpholinoethoxy)phenyl)urea
Type:
Small organic molecule
Emp. Form.:
C38H49FN4O4
Mol. Mass.:
644.8185
SMILES:
CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)Nc2ccc(F)cc2)c2cccc(OCCN3CCOCC3)c2)C1
Structure:
Search PDB for entries with ligand similarity: