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Target
RNA-directed RNA polymerase
Ligand
BDBM50186200
Substrate
n/a
Meas. Tech.
ChEMBL_366543 (CHEMBL871397)
IC50
96±n/a nM
Citation
 Rockway, TW; Zhang, R; Liu, D; Betebenner, DA; McDaniel, KF; Pratt, JK; Beno, D; Montgomery, D; Jiang, WW; Masse, S; Kati, WM; Middleton, T; Molla, A; Maring, CJ; Kempf, DJ Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring. Bioorg Med Chem Lett 16:3833-8 (2006) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50186200
Synonyms:
1-benzyl-4-hydroxy-3-(5-methyl-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1,2,4]thiadiazin-3-yl)-1H-[1,8]naphthyridin-2-one | CHEMBL379432
Type:
Small organic molecule
Emp. Form.:
C23H18N4O4S
Mol. Mass.:
446.478
SMILES:
Cc1cccc2c1N=C(NS2(=O)=O)c1c(O)c2cccnc2n(Cc2ccccc2)c1=O |c:8|
Structure:
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