Reaction Details Report a problem with these data
Target
Coagulation factor VII
Ligand
BDBM50180400
Substrate
n/a
Meas. Tech.
ChEMBL_366241 (CHEMBL863576)
Ki
1±n/a nM
Citation
Vijaykumar, D; Rai, R; Shaghafi, M; Ton, T; Torkelson, S; Leahy, EM; Riggs, JR; Hu, H; Sprengeler, PA; Shrader, WD; O'Bryan, C; Cabuslay, R; Sanford, E; Gjerstadt, E; Liu, L; Sukbuntherng, J; Young, WB Efforts toward oral bioavailability in factor VIIa inhibitors. Bioorg Med Chem Lett 16:3829-32 (2006) [PubMed] Article
More Info.:
Target
Name:
Coagulation factor VII
Synonyms:
Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:
Enzyme
Mol. Mass.:
51599.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
Inhibitor
Name:
BDBM50180400
Synonyms:
2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-5'-ureidomethyl-biphenyl-3-yl]-succinic acid | CHEMBL206387
Type:
Small organic molecule
Emp. Form.:
C26H24N6O7
Mol. Mass.:
532.5048
SMILES:
NC(=O)NCc1ccc(O)c(c1)-c1cc(cc(-c2nc3ccc(cc3[nH]2)C(N)=N)c1O)C(CC(O)=O)C(O)=O