Reaction Details Report a problem with these data
Target
Coagulation factor VII
Ligand
BDBM50186216
Substrate
n/a
Meas. Tech.
ChEMBL_366241 (CHEMBL863576)
Ki
5±n/a nM
Citation
 Vijaykumar, D; Rai, R; Shaghafi, M; Ton, T; Torkelson, S; Leahy, EM; Riggs, JR; Hu, H; Sprengeler, PA; Shrader, WD; O'Bryan, C; Cabuslay, R; Sanford, E; Gjerstadt, E; Liu, L; Sukbuntherng, J; Young, WB Efforts toward oral bioavailability in factor VIIa inhibitors. Bioorg Med Chem Lett 16:3829-32 (2006) [PubMed]  Article 
Target
Name:
Coagulation factor VII
Synonyms:
Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:
Enzyme
Mol. Mass.:
51599.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
  
Inhibitor
Name:
BDBM50186216
Synonyms:
2-(5-fluoro-2,2'-dihydroxy-5'-ureidomethyl-biphenyl-3-yl)-1H-benzoimidzole-5-carboxamidine | CHEMBL378947
Type:
Small organic molecule
Emp. Form.:
C22H19FN6O3
Mol. Mass.:
434.4231
SMILES:
NC(=O)NCc1ccc(O)c(c1)-c1cc(F)cc(-c2nc3ccc(cc3[nH]2)C(N)=N)c1O
Structure:
Search PDB for entries with ligand similarity: