Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 5
Ligand
BDBM50186384
Substrate
n/a
Meas. Tech.
ChEMBL_377653 (CHEMBL863682)
EC50
>10000±n/a nM
Citation
 Vachal, P; Toth, LM; Hale, JJ; Yan, L; Mills, SG; Chrebet, GL; Koehane, CA; Hajdu, R; Milligan, JA; Rosenbach, MJ; Mandala, S Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor. Bioorg Med Chem Lett 16:3684-7 (2006) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 5
Synonyms:
EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41796.42
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
398
Sequence:
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
  
Inhibitor
Name:
BDBM50186384
Synonyms:
3-(4-(5-(3-cyano-4-isopropoxyphenyl)-4-methylthiazol-2-yl)-3-methylphenyl)propanoic acid | CHEMBL210855
Type:
Small organic molecule
Emp. Form.:
C24H24N2O3S
Mol. Mass.:
420.524
SMILES:
CC(C)Oc1ccc(cc1C#N)-c1sc(nc1C)-c1ccc(CCC(O)=O)cc1C
Structure:
Search PDB for entries with ligand similarity: