Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 3
Ligand
BDBM50186402
Substrate
n/a
Meas. Tech.
ChEMBL_377652 (CHEMBL863681)
EC50
>10000±n/a nM
Citation
 Vachal, P; Toth, LM; Hale, JJ; Yan, L; Mills, SG; Chrebet, GL; Koehane, CA; Hajdu, R; Milligan, JA; Rosenbach, MJ; Mandala, S Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor. Bioorg Med Chem Lett 16:3684-7 (2006) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 3
Synonyms:
C9orf108 | C9orf47 | EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | S1PR3_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42278.13
Organism:
Homo sapiens (Human)
Description:
Q99500
Residue:
378
Sequence:
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN
  
Inhibitor
Name:
BDBM50186402
Synonyms:
3-(4-(5-(3-cyano-4-isopropoxyphenyl)thiazol-2-yl)-3-methylphenyl)propanoic acid | CHEMBL211046
Type:
Small organic molecule
Emp. Form.:
C23H22N2O3S
Mol. Mass.:
406.497
SMILES:
CC(C)Oc1ccc(cc1C#N)-c1cnc(s1)-c1ccc(CCC(O)=O)cc1C
Structure:
Search PDB for entries with ligand similarity: