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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50605031
Substrate
n/a
Meas. Tech.
ChEMBL_2249885 (CHEMBL5164095)
IC50
0.700000±n/a nM
Citation
 Grychowska, K; Olejarz-Maciej, A; Blicharz, K; Pietru?, W; Karcz, T; Kurczab, R; Koczurkiewicz, P; Doroz-P?onka, A; Latacz, G; Keeri, AR; Piska, K; Sata?a, G; P?giel, J; Tryba?a, W; Jastrz?bska-Wi?sek, M; Bojarski, AJ; Lamaty, F; Partyka, A; Walczak, M; Krawczyk, M; Malikowska-Racia, N; Popik, P; Zajdel, P Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines. Eur J Med Chem 236:0 (2022) [PubMed] 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM50605031
Synonyms:
CHEMBL5174789
Type:
Small organic molecule
Emp. Form.:
C25H27N3O2
Mol. Mass.:
401.5008
SMILES:
COC1CCN(CC1)c1nc2ccccc2c2n(Cc3cccc(OC)c3)ccc12
Structure:
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