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Target
Proteasome subunit beta type-5
Ligand
BDBM50186694
Substrate
n/a
Meas. Tech.
ChEMBL_353294 (CHEMBL861973)
IC50
17±n/a nM
Citation
 Rydzewski, RM; Burrill, L; Mendonca, R; Palmer, JT; Rice, M; Tahilramani, R; Bass, KE; Leung, L; Gjerstad, E; Janc, JW; Pan, L Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and cellular properties of potent, selective proteasome inhibitors. J Med Chem 49:2953-68 (2006) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50186694
Synonyms:
CHEMBL207336 | benzoyl-Glu(OtBu)-Ala-LeuVSMe
Type:
Small organic molecule
Emp. Form.:
C27H41N3O7S
Mol. Mass.:
551.695
SMILES:
CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c1ccccc1)\C=C\S(C)(=O)=O
Structure:
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