Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50186829
Substrate
n/a
Meas. Tech.
ChEMBL_376573 (CHEMBL866622)
Ki
52±n/a nM
Citation
 Wu, WL; Burnett, DA; Caplen, MA; Domalski, MS; Bennett, C; Greenlee, WJ; Hawes, BE; O'Neill, K; Weig, B; Weston, D; Spar, B; Kowalski, T Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett 16:3674-8 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50186829
Synonyms:
4'-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5,6-difluoro-1H-benzoimidazol-2-yl)-methyl]-biphenyl-3-carbonitrile | CHEMBL211956
Type:
Small organic molecule
Emp. Form.:
C30H26F2N4
Mol. Mass.:
480.551
SMILES:
Fc1cc2nc([nH]c2cc1F)C(=C1CCN(CC2CC2)CC1)c1ccc(cc1)-c1cccc(c1)C#N |(27.1,-.72,;25.56,-.72,;24.79,-2.05,;23.25,-2.05,;22.23,-3.2,;20.83,-2.57,;20.99,-1.04,;22.49,-.72,;23.25,.61,;24.78,.61,;25.55,1.95,;19.5,-3.34,;19.5,-4.88,;18.16,-5.64,;18.16,-7.18,;19.49,-7.95,;19.49,-9.49,;18.15,-10.26,;16.61,-10.26,;17.38,-11.6,;20.82,-7.18,;20.83,-5.64,;18.16,-2.57,;16.82,-3.35,;15.49,-2.58,;15.49,-1.03,;16.82,-.26,;18.16,-1.03,;14.16,-.26,;12.83,-1.03,;11.5,-.27,;11.5,1.28,;12.83,2.05,;14.16,1.28,;12.83,3.6,;12.83,5.14,)|
Structure:
Search PDB for entries with ligand similarity: