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Target
Nuclear receptor subfamily 5 group A member 2
Ligand
BDBM50605641
Substrate
n/a
Meas. Tech.
ChEMBL_2252393 (CHEMBL5166603)
EC50
43±n/a nM
Citation
 Cato, ML; Cornelison, JL; Spurlin, RM; Courouble, VV; Patel, AB; Flynn, AR; Johnson, AM; Okafor, CD; Frank, F; D'Agostino, EH; Griffin, PR; Jui, NT; Ortlund, EA Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket. J Med Chem 65:6888-6902 (2022) [PubMed] 
Target
Name:
Nuclear receptor subfamily 5 group A member 2
Synonyms:
Alpha-1-fetoprotein transcription factor | B1-binding factor | B1F | CPF | CYP7A promoter-binding factor | FTF | Hepatocytic transcription factor | LRH-1 | Liver Receptor Homolog 1 | NR5A2 | NR5A2_HUMAN | Nuclear receptor subfamily 5 group A member 2 | hB1F | nuclear receptor subfamily 5 group A member 2 isoform 2
Type:
Nuclear Hormone Receptor
Mol. Mass.:
61341.37
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
541
Sequence:
MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA
  
Inhibitor
Name:
BDBM50605641
Synonyms:
CHEMBL5177743
Type:
Small organic molecule
Emp. Form.:
C32H42N2O4S
Mol. Mass.:
550.752
SMILES:
NS(=O)(=O)N[C@H]1CC[C@@]2(C1CC(CCCCCCCCCC(O)=O)=C2c1ccccc1)C(=C)c1ccccc1 |r,c:24|
Structure:
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