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Target
Mitogen-activated protein kinase 11
Ligand
BDBM50605782
Substrate
n/a
Meas. Tech.
ChEMBL_2252846 (CHEMBL5167056)
IC50
0.100000±n/a nM
Citation
 Armani, E; Capaldi, C; Bagnacani, V; Saccani, F; Aquino, G; Puccini, P; Facchinetti, F; Martucci, C; Moretto, N; Villetti, G; Patacchini, R; Civelli, M; Hurley, C; Jennings, A; Alcaraz, L; Bloomfield, D; Briggs, M; Daly, S; Panchal, T; Russell, V; Wicks, S; Finch, H; Fitzgerald, M; Fox, C; Delcanale, M Design, Synthesis, and Biological Characterization of Inhaled p38?/? MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases. J Med Chem 65:7170-7192 (2022) [PubMed] 
Target
Name:
Mitogen-activated protein kinase 11
Synonyms:
MAP kinase p38 | MAPK11 | MK11_HUMAN | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | PRKM11 | SAPK2 | SAPK2B | Stress-activated protein kinase 2 | p38 MAP kinase alpha/beta | p38-2 | p38-beta | p38b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41351.73
Organism:
Homo sapiens (Human)
Description:
gi_20128774
Residue:
364
Sequence:
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSLEIEQ
  
Inhibitor
Name:
BDBM50605782
Synonyms:
CHEMBL5174953
Type:
Small organic molecule
Emp. Form.:
C38H51N11O2
Mol. Mass.:
693.884
SMILES:
C[C@H]1CCC[C@@H](C)N1c1nnc2ccc(O[C@@H]3CC[C@H](NC(=O)Nc4cc(nn4-c4cnn(CCN(C)C)c4)C(C)(C)C)c4ccccc34)cn12 |r|
Structure:
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