Reaction Details
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B-cell lymphoma 6 protein
Ligand
BDBM50606284
Substrate
n/a
Meas. Tech.
ChEMBL_2254352 (CHEMBL5168562)
IC50
3.5±n/a nM
Citation
Huckvale, R; Harnden, AC; Cheung, KJ; Pierrat, OA; Talbot, R; Box, GM; Henley, AT; de Haven Brandon, AK; Hallsworth, AE; Bright, MD; Akpinar, HA; Miller, DSJ; Tarantino, D; Gowan, S; Hayes, A; Gunnell, EA; Brennan, A; Davis, OA; Johnson, LD; de Klerk, S; McAndrew, C; Le Bihan, YV; Meniconi, M; Burke, R; Kirkin, V; van Montfort, RLM; Raynaud, FI; Rossanese, OW; Bellenie, BR; Hoelder, S Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 J Med Chem 65:8191-8207 (2022) [PubMed] More Info.:
Target
Name:
B-cell lymphoma 6 protein
Synonyms:
B-cell lymphoma 5 protein | B-cell lymphoma 6 protein | BCL-5 | BCL-6 | BCL5 | BCL6 | BCL6_HUMAN | BCoR-BCL6 | LAZ3 | Protein LAZ-3 | ZBTB27 | ZNF51 | Zinc finger and BTB domain-containing protein 27 | Zinc finger protein 51
Type:
PROTEIN
Mol. Mass.:
78866.89
Organism:
Homo sapiens
Description:
ChEMBL_117695
Residue:
706
Sequence:
MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFIKASEAEMVSAIKPPREEFLNSRMLMPQDIMAYRGREVVENNLPLRSAPGCESRAFAPSLYSGLSTPPASYSMYSHLPVSSLLFSDEEFRDVRMPVANPFPKERALPCDSARPVPGEYSRPTLEVSPNVCHSNIYSPKETIPEEARSDMHYSVAEGLKPAAPSARNAPYFPCDKASKEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESCSSKNACILQASGSPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPMEPENLDLQSPTKLSASGEDSTIPQASRLNNIVNRSMTGSPRSSSESHSPLYMHPPKCTSCGSQSPQHAEMCLHTAGPTFPEEMGETQSEYSDSSCENGAFFCNECDCRFSEEASLKRHTLQTHSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSATDLPPELPKAC
Inhibitor
Name:
BDBM50606284
Synonyms:
CHEMBL5208698
Type:
Small organic molecule
Emp. Form.:
C25H25ClF4N6O3
Mol. Mass.:
568.951
SMILES:
Cn1c2ccc(Nc3nc(ncc3Cl)N3CCC(F)(F)[C@@H](O)C3)cc2c2N[C@@H](C3CC3)C(F)(F)COc2c1=O |r|
Structure:
