Reaction Details
Report a problem with these data
Report a problem with these dataTarget
B-cell lymphoma 6 protein
Ligand
BDBM50511632
Substrate
n/a
Meas. Tech.
ChEMBL_2254353 (CHEMBL5168563)
EC50
54±n/a nM
Citation
Huckvale, R; Harnden, AC; Cheung, KJ; Pierrat, OA; Talbot, R; Box, GM; Henley, AT; de Haven Brandon, AK; Hallsworth, AE; Bright, MD; Akpinar, HA; Miller, DSJ; Tarantino, D; Gowan, S; Hayes, A; Gunnell, EA; Brennan, A; Davis, OA; Johnson, LD; de Klerk, S; McAndrew, C; Le Bihan, YV; Meniconi, M; Burke, R; Kirkin, V; van Montfort, RLM; Raynaud, FI; Rossanese, OW; Bellenie, BR; Hoelder, S Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 J Med Chem 65:8191-8207 (2022) [PubMed] More Info.:
Target
Name:
B-cell lymphoma 6 protein
Synonyms:
B-cell lymphoma 5 protein | B-cell lymphoma 6 protein | BCL-5 | BCL-6 | BCL5 | BCL6 | BCL6_HUMAN | BCoR-BCL6 | LAZ3 | Protein LAZ-3 | ZBTB27 | ZNF51 | Zinc finger and BTB domain-containing protein 27 | Zinc finger protein 51
Type:
PROTEIN
Mol. Mass.:
78866.89
Organism:
Homo sapiens
Description:
ChEMBL_117695
Residue:
706
Sequence:
MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFIKASEAEMVSAIKPPREEFLNSRMLMPQDIMAYRGREVVENNLPLRSAPGCESRAFAPSLYSGLSTPPASYSMYSHLPVSSLLFSDEEFRDVRMPVANPFPKERALPCDSARPVPGEYSRPTLEVSPNVCHSNIYSPKETIPEEARSDMHYSVAEGLKPAAPSARNAPYFPCDKASKEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESCSSKNACILQASGSPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPMEPENLDLQSPTKLSASGEDSTIPQASRLNNIVNRSMTGSPRSSSESHSPLYMHPPKCTSCGSQSPQHAEMCLHTAGPTFPEEMGETQSEYSDSSCENGAFFCNECDCRFSEEASLKRHTLQTHSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSATDLPPELPKAC
Inhibitor
Name:
BDBM50511632
Synonyms:
CHEMBL4445645
Type:
Small organic molecule
Emp. Form.:
C24H31ClF2N6O2
Mol. Mass.:
508.992
SMILES:
C[C@H]1CN(C[C@@H](C)C1(F)F)c1ncc(Cl)c(Nc2ccc3n(C)c(=O)n(CCC(C)(C)O)c3c2)n1 |r|
Structure:
