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Target
C-X-C chemokine receptor type 1
Ligand
BDBM50187001
Substrate
n/a
Meas. Tech.
ChEMBL_2260010 (CHEMBL5215021)
IC50
36±n/a nM
Citation
 Chasák, J; ?lachtová, V; Urban, M; Brulíková, L Squaric acid analogues in medicinal chemistry. Eur J Med Chem 209:0 (2021) [PubMed] 
Target
Name:
C-X-C chemokine receptor type 1
Synonyms:
C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:
Enzyme
Mol. Mass.:
39803.83
Organism:
Homo sapiens (Human)
Description:
P25024
Residue:
350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
  
Inhibitor
Name:
BDBM50187001
Synonyms:
3-(2-hydroxy-4-nitrophenylamino)-4-(phenylamino)cyclobut-3-ene-1,2-dione | CHEMBL379438
Type:
Small organic molecule
Emp. Form.:
C16H11N3O5
Mol. Mass.:
325.2756
SMILES:
Oc1cc(ccc1Nc1c(Nc2ccccc2)c(=O)c1=O)[N+]([O-])=O
Structure:
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