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Target
Cysteine protease ATG4A
Ligand
BDBM50370218
Substrate
n/a
Meas. Tech.
ChEMBL_2260029 (CHEMBL5215040)
IC50
1300±n/a nM
Citation
 Yang, G; Li, Y; Zhao, Y; Ouyang, L; Chen, Y; Liu, B; Liu, J Targeting Atg4B for cancer therapy: Chemical mediators. Eur J Med Chem 209:0 (2021) [PubMed] 
Target
Name:
Cysteine protease ATG4A
Synonyms:
3.4.22.- | APG4A | ATG4A | ATG4A_HUMAN | AUT-like 2 cysteine endopeptidase | AUTL2 | AUTL2 GN | Autophagin-2 | Autophagy-related cysteine endopeptidase 2 | Autophagy-related protein 4 homolog A | HsAPG4A | Synonyms=APG4A | hAPG4A
Type:
PROTEIN
Mol. Mass.:
45363.77
Organism:
Homo sapiens
Description:
ChEMBL_120720
Residue:
398
Sequence:
MESVLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIEDIKKMCRVLPLSADTAGDRPPDSLTASNQSKGTSAYCSAWKPLLLIVPLRLGINQINPVYVDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTEENGTVNDQTFHCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPSHWPPFVPPAKPEVTTTGAEFIDSTEQLEEFDLEEDFEILSV
  
Inhibitor
Name:
BDBM50370218
Synonyms:
TIOCONAZOLE
Type:
Small organic molecule
Emp. Form.:
C16H13Cl3N2OS
Mol. Mass.:
387.711
SMILES:
Clc1sccc1COC(Cn1ccnc1)c1ccc(Cl)cc1Cl
Structure:
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