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Target
Protein-S-isoprenylcysteine O-methyltransferase
Ligand
BDBM50189243
Substrate
n/a
Meas. Tech.
ChEMBL_380404 (CHEMBL864903)
IC50
23000±n/a nM
Citation
 Donelson, JL; Hodges, HB; Macdougall, DD; Henriksen, BS; Hrycyna, CA; Gibbs, RA Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase. Bioorg Med Chem Lett 16:4420-3 (2006) [PubMed]  Article 
Target
Name:
Protein-S-isoprenylcysteine O-methyltransferase
Synonyms:
ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT
Type:
PROTEIN
Mol. Mass.:
31943.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_956034
Residue:
284
Sequence:
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFTAGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTVWRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
  
Inhibitor
Name:
BDBM50189243
Synonyms:
(R)-2-(3,5-dichlorobenzamido)-3-(3,7,11-trimethyldodeca-2,6,10-trienylthio)propanoic acid | CHEMBL209435
Type:
Small organic molecule
Emp. Form.:
C25H33Cl2NO3S
Mol. Mass.:
498.505
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#16]-[#6]-[#6@H](-[#7]-[#6](=O)-c1cc(Cl)cc(Cl)c1)-[#6](-[#8])=O
Structure:
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