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Target
Target of rapamycin complex subunit LST8
Ligand
BDBM50606702
Substrate
n/a
Meas. Tech.
ChEMBL_2261179 (CHEMBL5216190)
IC50
<0.100000±n/a nM
Citation
 Oleksak, P; Nepovimova, E; Chrienova, Z; Musilek, K; Patocka, J; Kuca, K Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015-2021). Eur J Med Chem 238:0 (2022) [PubMed] 
Target
Name:
Target of rapamycin complex subunit LST8
Synonyms:
G protein beta subunit-like | GBL | Gable | LST8 | LST8_HUMAN | MLST8 | Mammalian lethal with SEC13 protein 8 | Protein GbetaL | TORC subunit LST8 | Target of rapamycin complex subunit LST8
Type:
PROTEIN
Mol. Mass.:
35871.25
Organism:
Homo sapiens
Description:
ChEMBL_118692
Residue:
326
Sequence:
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVLG
  
Inhibitor
Name:
BDBM50606702
Synonyms:
CHEMBL5219001
Type:
Small organic molecule
Emp. Form.:
C66H109NO21
Mol. Mass.:
1252.5658
SMILES:
[H][C@@]12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@@]([H])(CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C2)OCCOCCOCCOCCOCCOCCOCCOCCO)[C@H](C)C[C@@H]1CC[C@@H](O)[C@@H](C1)OC |r,c:31,50,t:46,48|
Structure:
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