Reaction Details Report a problem with these data
Target
Egl nine homolog 1
Ligand
BDBM50607011
Substrate
n/a
Meas. Tech.
ChEMBL_2261966 (CHEMBL5216977)
EC50
100±n/a nM
Citation
 Zhi, S; Cai, J; Wang, H; Tan, C; Yang, Z; Dai, L; Zhang, T; Wang, H; Li, D Synthesis and biological evaluation of (4-hydroxy-2-(substitued sulfonamido)pyrimidine-5-carbonyl)glycines as oral erythropoietin secretagogues. Bioorg Med Chem Lett 76:0 (2022) [PubMed] 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM50607011
Synonyms:
CHEMBL5219277
Type:
Small organic molecule
Emp. Form.:
C19H16N4O6S
Mol. Mass.:
428.419
SMILES:
OC(=O)CNC(=O)c1cnc(NS(=O)(=O)c2ccc(cc2)-c2ccccc2)nc1O
Structure:
Search PDB for entries with ligand similarity: