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Target
Kappa-type opioid receptor
Ligand
BDBM50194398
Substrate
n/a
Meas. Tech.
ChEMBL_424357 (CHEMBL909560)
Ki
>1000±n/a nM
Citation
 Lee, DY; He, M; Liu-Chen, LY; Wang, Y; Li, JG; Xu, W; Ma, Z; Carlezon, WA; Cohen, B Synthesis and in vitro pharmacological studies of new C(4)-modified salvinorin A analogues. Bioorg Med Chem Lett 16:5498-502 (2006) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50194398
Synonyms:
CHEMBL384366 | [(9H-fluoren-9-ylmethoxycarbonylamino)]-phenyl-acetic acid (3S,4aR,4bS,6S,8R,8aS,10aR)-6-acetoxy-3-furan-3-yl-4a,8a-dimethyl-1,5-dioxo-dodecahydro-2-oxa-phenanthren-8-ylmethyl ester
Type:
Small organic molecule
Emp. Form.:
C45H45NO10
Mol. Mass.:
759.8395
SMILES:
CC(=O)O[C@H]1C[C@@H](COC(=O)C(NC(=O)OCC2c3ccccc3-c3ccccc23)c2ccccc2)[C@]2(C)CC[C@H]3C(=O)O[C@@H](C[C@]3(C)[C@H]2C1=O)c1ccoc1
Structure:
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