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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50194626
Substrate
n/a
Meas. Tech.
ChEMBL_396482 (CHEMBL911536)
IC50
1398±n/a nM
Citation
 Xu, Y; Etgen, GJ; Broderick, CL; Canada, E; Gonzalez, I; Lamar, J; Montrose-Rafizadeh, C; Oldham, BA; Osborne, JJ; Xie, C; Shi, Q; Winneroski, LL; York, J; Yumibe, N; Zink, R; Mantlo, N Design and synthesis of dual peroxisome proliferator-activated receptors gamma and delta agonists as novel euglycemic agents with a reduced weight gain profile. J Med Chem 49:5649-52 (2006) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50194626
Synonyms:
2-(4-(3-(2-benzoyl-4-ethylphenoxy)propoxy)phenoxy)-2-methylpropanoic acid | CHEMBL213314
Type:
Small organic molecule
Emp. Form.:
C28H30O6
Mol. Mass.:
462.5342
SMILES:
CCc1ccc(OCCCOc2ccc(OC(C)(C)C(O)=O)cc2)c(c1)C(=O)c1ccccc1
Structure:
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