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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50195215
Substrate
n/a
Meas. Tech.
ChEMBL_424833 (CHEMBL908460)
IC50
12±n/a nM
Citation
 Huang, S; Garbaccio, RM; Fraley, ME; Steen, J; Kreatsoulas, C; Hartman, G; Stirdivant, S; Drakas, B; Rickert, K; Walsh, E; Hamilton, K; Buser, CA; Hardwick, J; Mao, X; Abrams, M; Beck, S; Tao, W; Lobell, R; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Murphy, JZ; Sardana, V; Munshi, S; Kuo, L; Reilly, M; Mahan, E Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors. Bioorg Med Chem Lett 16:5907-12 (2006) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50195215
Synonyms:
3-(5-((4-(aminomethyl)piperidin-1-yl)methyl)-1H-indol-2-yl)-1H-indazole-6-carbonitrile | 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)-1H-INDAZOLE-6-CARBONITRILE | CHEMBL221181
Type:
Small organic molecule
Emp. Form.:
C23H24N6
Mol. Mass.:
384.4769
SMILES:
NCC1CCN(Cc2ccc3[nH]c(cc3c2)-c2n[nH]c3cc(ccc23)C#N)CC1
Structure:
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