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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50195213
Substrate
n/a
Meas. Tech.
ChEMBL_424834 (CHEMBL908461)
EC50
97±n/a nM
Citation
Huang, S; Garbaccio, RM; Fraley, ME; Steen, J; Kreatsoulas, C; Hartman, G; Stirdivant, S; Drakas, B; Rickert, K; Walsh, E; Hamilton, K; Buser, CA; Hardwick, J; Mao, X; Abrams, M; Beck, S; Tao, W; Lobell, R; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Murphy, JZ; Sardana, V; Munshi, S; Kuo, L; Reilly, M; Mahan, E Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors. Bioorg Med Chem Lett 16:5907-12 (2006) [PubMed] Article
More Info.:
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
Inhibitor
Name:
BDBM50195213
Synonyms:
3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)-6-(1H-pyrazol-4-yl)quinolin-2(1H)-one | 3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-6-(1H-PYRAZOL-4-YL)QUINOLIN-2(1H)-ONE | CHEMBL374662
Type:
Small organic molecule
Emp. Form.:
C26H25N5O
Mol. Mass.:
423.5096
SMILES:
O=c1[nH]c2ccc(cc2cc1-c1cc2cc(CN3CCCCC3)ccc2[nH]1)-c1cn[nH]c1