Reaction Details Report a problem with these data
Target
Cholecystokinin receptor type A
Ligand
BDBM50196179
Substrate
n/a
Meas. Tech.
ChEMBL_418718 (CHEMBL913512)
Ki
>10000±n/a nM
Citation
 Allison, BD; Phuong, VK; McAtee, LC; Rosen, M; Morton, M; Prendergast, C; Barrett, T; Lagaud, G; Freedman, J; Li, L; Wu, X; Venkatesan, H; Pippel, M; Woods, C; Rizzolio, MC; Hack, M; Hoey, K; Deng, X; King, C; Shankley, NP; Rabinowitz, MH Identification and optimization of anthranilic sulfonamides as novel, selective cholecystokinin-2 receptor antagonists. J Med Chem 49:6371-90 (2006) [PubMed]  Article 
Target
Name:
Cholecystokinin receptor type A
Synonyms:
CCK-A receptor | CCK-AR | CCK1-R | CCKAR | CCKAR_HUMAN | CCKRA | Cholecystokinin receptor | Cholecystokinin receptor type A | Cholecystokinin-1 Receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
47859.34
Organism:
Homo sapiens (Human)
Description:
Stable expression of human CCK-1 receptors in HEK 293 cells.
Residue:
428
Sequence:
MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSHMSASVPPQ
  
Inhibitor
Name:
BDBM50196179
Synonyms:
4-[4-bromo-2-[(5-quinoxalinylsulfonyl)amino]benzoyl]-morpholine | CHEMBL215416
Type:
Small organic molecule
Emp. Form.:
C19H17BrN4O4S
Mol. Mass.:
477.332
SMILES:
Brc1ccc(C(=O)N2CCOCC2)c(NS(=O)(=O)c2cccc3nccnc23)c1
Structure:
Search PDB for entries with ligand similarity: