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Target
Serine/threonine-protein kinase Chk2
Ligand
BDBM50196389
Substrate
n/a
Meas. Tech.
ChEMBL_458796 (CHEMBL942096)
IC50
5000±n/a nM
Citation
 Larson, G; Yan, S; Chen, H; Rong, F; Hong, Z; Wu, JZ Identification of novel, selective and potent Chk2 inhibitors. Bioorg Med Chem Lett 17:172-5 (2006) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk2
Synonyms:
CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | RAD53 | Serine/threonine-protein kinase Chek2 | Serine/threonine-protein kinase Chk1/2
Type:
Protein
Mol. Mass.:
60908.59
Organism:
Homo sapiens (Human)
Description:
O96017
Residue:
543
Sequence:
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL
  
Inhibitor
Name:
BDBM50196389
Synonyms:
5-(4-benzoyl-phenylamino)-N-cyclohexylmethyl-3-hydroxy-isothiazole-4-carboxamidine | CHEMBL249253
Type:
Small organic molecule
Emp. Form.:
C24H26N4O2S
Mol. Mass.:
434.554
SMILES:
NC(=NCC1CCCCC1)c1c(Nc2ccc(cc2)C(=O)c2ccccc2)s[nH]c1=O |w:2.2|
Structure:
Search PDB for entries with ligand similarity: