Reaction Details Report a problem with these data
Target
Excitatory amino acid transporter 3
Ligand
BDBM50197104
Substrate
n/a
Meas. Tech.
ChEMBL_406820 (CHEMBL907704)
Ki
49000±n/a nM
Citation
 Faure, S; Jensen, AA; Maurat, V; Gu, X; Sagot, E; Aitken, DJ; Bolte, J; Gefflaut, T; Bunch, L Stereoselective chemoenzymatic synthesis of the four stereoisomers of l-2-(2-carboxycyclobutyl)glycine and pharmacological characterization at human excitatory amino acid transporter subtypes 1, 2, and 3. J Med Chem 49:6532-8 (2006) [PubMed]  Article 
Target
Name:
Excitatory amino acid transporter 3
Synonyms:
EAA3_HUMAN | EAAC1 | EAAT3 | Excitatory Amino Acid EAAT3 | HEAAC1 | SLC1A1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57096.71
Organism:
Homo sapiens (Human)
Description:
Excitatory Amino Acid EAAT3 0 HUMAN::P43005
Residue:
524
Sequence:
MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVNIVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
  
Inhibitor
Name:
BDBM50197104
Synonyms:
(2S,1'R,2'R)-2-(2'-Carboxycyclobutyl)glycine | CHEMBL217407
Type:
Small organic molecule
Emp. Form.:
C7H11NO4
Mol. Mass.:
173.1665
SMILES:
N[C@@H]([C@@H]1CC[C@H]1C(O)=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: