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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50197476
Substrate
n/a
Meas. Tech.
ChEMBL_432257 (CHEMBL914035)
IC50
5370±n/a nM
Citation
 Pham-Huu, DP; Deschamps, JR; Liu, S; Madras, BK; Meltzer, PC Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters. Bioorg Med Chem 15:1067-82 (2006) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
SC6A4_MACMU | SLC6A4 | Serotonin transporter
Type:
PROTEIN
Mol. Mass.:
70256.94
Organism:
Macaca mulatta
Description:
ChEMBL_432257
Residue:
630
Sequence:
METTPLNSQKQLSACKDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPAATTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLIPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIILGYCIGTSSFVCIPTYIAYRLISTPGTFKERIIKSITPETPTEIPCGDVRLNAV
  
Inhibitor
Name:
BDBM50197476
Synonyms:
(1S,7R)-methyl 3-(3,4-dichlorophenyl)-7-hydroxy-8-methyl-8-aza-bicyclo[3.2.1]oct-2-ene-2-carboxylate | CHEMBL388608
Type:
Small organic molecule
Emp. Form.:
C16H17Cl2NO3
Mol. Mass.:
342.217
SMILES:
COC(=O)C1=C(CC2C[C@@H](O)[C@H]1N2C)c1ccc(Cl)c(Cl)c1 |t:4,TLB:14:5:12:9.8,THB:10:9:12:4.5.6,2:4:12:9.8|
Structure:
Search PDB for entries with ligand similarity: