Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50197994
Substrate
n/a
Meas. Tech.
ChEMBL_453298 (CHEMBL902453)
IC50
2840±n/a nM
Citation
 Pinkerton, AB; Huang, D; Cube, RV; Hutchinson, JH; Struthers, M; Ayala, JM; Vicario, PP; Patel, SR; Wisniewski, T; DeMartino, JA; Vernier, JM Diaryl substituted pyrazoles as potent CCR2 receptor antagonists. Bioorg Med Chem Lett 17:807-13 (2007) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50197994
Synonyms:
(2S)-methyl 2-(4-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-pyrazol-5-yl)butanamido)-3-(1H-imidazol-4-yl)propanoate | CHEMBL241498
Type:
Small organic molecule
Emp. Form.:
C30H27Cl2N5O3
Mol. Mass.:
576.473
SMILES:
COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCCc1cc(nn1-c1ccc2ccccc2c1)-c1cc(Cl)cc(Cl)c1
Structure:
Search PDB for entries with ligand similarity: