Reaction Details Report a problem with these data
Target
Deoxyhypusine synthase
Ligand
BDBM50612294
Substrate
n/a
Meas. Tech.
ChEMBL_2286803
IC50
9.2±n/a nM
Citation
 Tanaka, Y; Kurasawa, O; Yokota, A; Klein, MG; Saito, B; Matsumoto, S; Okaniwa, M; Ambrus-Aikelin, G; Uchiyama, N; Morishita, D; Kimura, H; Imamura, S New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase. ACS Med Chem Lett 11:1645-1652 (2020) [PubMed] 
Target
Name:
Deoxyhypusine synthase
Synonyms:
2.5.1.46 | DHPS | DHS | DHYS_HUMAN | DS | Deoxyhypusine synthase
Type:
PROTEIN
Mol. Mass.:
40962.06
Organism:
Homo sapiens
Description:
ChEMBL_18047
Residue:
369
Sequence:
MEGSLEREAPAGALAAVLKHSSTLPPESTQVRGYDFNRGVNYRALLEAFGTTGFQATNFGRAVQQVNAMIEKKLEPLSQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNENYCKFEDWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVFSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKCTGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQKMDAFMHEKNED
  
Inhibitor
Name:
BDBM50612294
Synonyms:
CHEMBL5281395
Type:
Small organic molecule
Emp. Form.:
C18H23N3OS
Mol. Mass.:
329.46
SMILES:
CC(C)C[C@H](CN)N1CCc2c(csc2C1=O)-c1cccnc1 |r|
Structure:
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