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Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50072989
Substrate
n/a
Meas. Tech.
ChEMBL_441055 (CHEMBL890212)
Ki
1500±n/a nM
Citation
 Grunewald, GL; Seim, MR; Regier, RC; Criscione, KR Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitors. Bioorg Med Chem 15:1298-310 (2007) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT)
Type:
Enzyme
Mol. Mass.:
30852.66
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
282
Sequence:
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
  
Inhibitor
Name:
BDBM50072989
Synonyms:
1,2,3,4-Tetrahydro-isoquinoline-7-carbonitrile | 1,2,3,4-tetrahydroisoquinoline-7-carbonitrile | CHEMBL27162
Type:
Small organic molecule
Emp. Form.:
C10H10N2
Mol. Mass.:
158.1998
SMILES:
N#Cc1ccc2CCNCc2c1
Structure:
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